A new osteoporosis drug? Antibody for a protein known to inhibit bone growth   

The search is endlessly on for a safe, effective osteoporosis treatment. One that may hit the market in 2017 inhibits the actions of a naturally-occurring protein, sclerostin. Sclerostin interferes with a signalling pathway (the Wnt signaling pathway) that spurs osteoblasts to grow bone. Sclerostin is secreted by osteoctyes embedded in bone matrix and seems to be a feedback mechanism to keep bones from growing too thick.  If you inhibit sclerostin, as is seen in some disease states, you increase bone mass and strength.

Recently scientists have crystallized the antibody, and two pharmaceutical companies are moving ahead with clinical trials. They say the results are positive and that the drug could be available this year.

The clinical trials so far have been for 12 months, during which time no severe side effects were listed.  It remains to be determined how long and how often treatment would be recommended.

It also remains unknown how long-term inhibition of sclerostin will affect the body as a whole.


Sclerostin Antibody Therapy for the Treatment of Osteoporosis:
Clinical Prospects and Challenges

Following a fracture, a physician must review all medications for potential contribution to bone fragility 

The majority of older individuals who sustain a fragility fracture have recently taken prescription drugs that are associated with an increased fracture risk—and a similar percentage continue to receive these agents after the fracture, suggest results of a recent study that highlights a missed opportunity to reduce secondary fractures.– Melinda B. Tanzola, PhD in The Puzzling Use of Drugs that Increase Fracture Risk

About one in two women and one in four men over age fifty will break an osteoporotic bone. Some of us won’t be surprised: We know our bone mineral is meager or our bones are overly stiff; others, many times men, don’t know until the fracture. So would you be surprised to find that following an osteoporotic fissure, few physicians review medications to see whether any in the armory of the patient’s pumps or pills is known to cause osteoporosis? That’s exactly what Sarah D. Berry and her Harvard Colleague Douglas P. Kiel found to be the case and the consequences of the lapse cannot be overstated: to cite just two shocking facts, the incidence of osteoporotic fracture is greater than heart attack, stroke and breast cancer combined; and, among those who fracture a hip 21% will die in the first year.

Dr. Berry says that a fracture patient’s physician should review three groups of medicines:

  • drugs that increase fall risk, which include antidepressants, benzodiazepines and sleeping pills (e.g., zolpidem or Ambien)
  • drugs that decrease bone density, principally though not only proton pump inhibitors, long known to the medical community (though rarely communicated to the public) as cause of osteoporosis and prednisone, a potent anti-inflammatory drug which WebMD reports as prescribed for many and varied conditions such as arthritis, blood disorders, breathing problems, severe allergies, skin diseases, cancer, eye problems, and immune system disorders. Prednisone belongs to a class of drugs known as corticosteroids. While steroids except those applied to the skin are considered osteoporosis risk, even in small doses prednisone is a known osteoporosis risk.
  • drugs with unclear fracture risk mechanism

Ideally, always confirm with your physician that there is no herbal, dietary, environmental or activity alternative to drugs that have a known causal link to osteoporosis. This is essential if you suffer a fragility fracture.


Medication Review After a Fracture – Absolutely Essential
Sarah D. Berry MD/MPH and Douglas P. Kiel MD/MPH
JAMA Internal Medicine October 2016 Volume 176. Number 10

Invited Comment for
Patterns of Prescription Drug Use Before and After Fragility Fracture
Jeffrey C. Munson, MD, Julie P. W. Bynum et al JAMA Intern Med. 2016;176(10):1531-1538.

But….you won’t tell me to stop drinking coffee, will you?

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This is one of the most common questions a doctor gets, with nothing short of terror in some patients’ voices.

Coffee is a fascinating substance, and there are varying genetic types in terms of how your body processes coffee.  Most people can generally be safe drinking 2 cups a day without any problem (though certain genetic types see a rise in cardiovascular events at more than 2 cups per day). But in terms of bone health there are a couple of considerations before giving coffee the seal of approval.

Generally speaking, any foods that you eat or drink that are acidic have the theoretical potential to cause bone loss. In order to understand this we will need a quick chemistry lesson:

An acid is a substance that donates hydrogen ions. Because of this, when an acidic substance like coffee enters the body, the balance between hydrogen ions and hydroxide ions is shifted. Now there are more hydrogen ions than hydroxide ions in the solution. This solution is acidic.

The opposite is a base substance, one that “soaks up” hydrogen ions. This kind of solution is alkaline.

Acid and base are measured in pH, in comparison to pure water. Pure water is neutral pH, in the middle, at 7. Black coffee is 100 times more acidic than pure water, and baking soda is 100 times more alkaline than pure water.

Our blood pH is very tightly regulated between 7.35 and 7.45. Blood pH regulation is one of the most tightly controlled numbers in our bodies. Calcium is also very tightly regulated. The strict regulation of both blood pH and calcium indicate how vital the right balances are to a well-functioning system.

Our bodies control the acid/base balance through the kidneys, lungs, and a buffer system. The kidneys excrete excess acids or bases as required for proper pH balance. The lungs release carbon dioxide, which is acidic. The pH of the blood increases – becomes more base – as breathing becomes faster and deeper. By adjusting the speed and depth of breathing, the brain and lungs are able to regulate the blood pH minute by minute.

The buffer system consists of acids and bases (carbonates and bicarbonates) on hand to balance out the blood as the body’s environment shifts from metabolic processes producing acidic waste.

There is a lot of debate about the acid/base situation and how it affects the body and the bones. It is not true that the blood will shift outside of its tightly regulated parameters. But it is true that the blood must regulate itself exactly because the system around it, our body, is influenced by the foods we eat and the environment we live in – affecting acidity or alkalinity.


Western diets are generally high in acidic foods such as meat and grains – and coffee.

A diet of acidic foods can impose a high acidic load that can lead to a low level of metabolic acidosis.   At this point we will breathe out carbon dioxide, but the body might also draw calcium, which is alkaline, from the bones into the blood to help the buffer system counteract the acidic load.

When we look at one high quality study of 489 women published in the American Society of Clinical Nutrition, we find that caffeine does in fact increase the rate of bone loss – “Women with high caffeine intakes had significantly higher rates of bone loss at the spine than did those with low intakes.”

It was also noted in this study that women with a specific genetic variant in the Vitamin D receptor (the tt variant) were at greater risk for this deleterious effect.

It is only a correlation, and there may be other life style factors that go in hand with high coffee consumption that contribute to the bone loss.   But if we look at another high acidic load food that we eat a lot of, protein, we do not see bone loss necessarily but we do see increased calcium excretion. This paradox is  explained by the idea that although excess acid (protein in this case) load causes the body to pull calcium, the extra protein enhances bone growth.

So. It looks as if high coffee consumption may in fact impact bone mass. What’s a coffee lover to do?

First of all, you can ensure that you are helping your body stay in good health by eating a good variety of alkaline foods – vegetables, fruits and legumes. This will, among other things, balance the acidic foods.

It is also important to make sure you have sufficient minerals including calcium in your diet on a daily basis – then your body is less likely to draw calcium from your bones.

And directly, you can add chicory to your coffee. Chicory is alkaline, and also adds a delicious depth to the coffee, providing a natural balance to the acidity.

Calcium supplements may damage the heart, says Johns Hopkins, but not calcium in food


Taking calcium in the form of supplements may raise the risk of plaque buildup in arteries and heart damage, although a diet high in calcium-rich foods appears be protective says a team of researchers at Johns Hopkins.

This research is correlative, using medical records of nearly 3000 people over a ten year period – not direct cause and effect, but it clearly shows a relationship.

“When it comes to using vitamin and mineral supplements, particularly calcium supplements being taken for bone health, many Americans think that more is always better,” says Erin Michos, M.D., M.H.S., associate director of preventive cardiology and associate professor of medicine at the Ciccarone Center for the Prevention of Heart Disease at the Johns Hopkins University School of Medicine. “But our study adds to the body of evidence that excess calcium in the form of supplements may harm the heart and vascular system.”

We are happy to have our work confirmed by such a prestigious institution.





How the Pomegranate Heals You

pomegranate board.JPG


As we age our cellular powerhouses start to malfunction.  This breakdown is central to a theory on aging, the mitochondrial theory of aging.  If we could figure out how to keep our mitochondria not only intact but keep their numbers high, we may not age.

Recent work has shown that a substance provided by the pomegranate and also found in nuts and berries – urolithin A – helps the mitochondria keep house, to such a degree that rats and mice in age decline were able to exercise again.

However this star molecule does not come directly from the pomegranate.  It is a product of intestinal flora, when substances from the pomegranate are transformed by gut microbes.

Unfortunately microbial diversity is in severe decline in the West, and not everyone has the specific microbes to transform the mighty pomegranate into an age-defying  superfood.

So research is underway to deliver urolithin A directly to patients, circumventing the need for the right intestinal bacteria.  “By helping the body to renew itself, urolithin A could well succeed where so many pharmaceutical products, most of which have tried to increase muscle mass, have failed. The nutritional approach opens up territory that traditional pharma has never explored. It’s a true shift in the scientific paradigm.”

We couldn’t agree more, and it’s about time we came back around to real healing.